Lobo V*, Nowak I*,Fernandez C*, Correa Muler AI, Westholm JO, Huang H, Fabrik I, Huynh HT, Kanik M, Härtlova A, Benhalevy D, Angeletti D and Sarshad AA# Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference doi: https://doi.org/10.1101/2023.06.05.543674
Nowak I and Sarshad AA# Argonaute proteins take center stage in cancers. Cancers (2021); 13(4):788.
Rosshart SP#, Herz J*, Vassallo BG*, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I, Collins N, Blatter JA, Han S, Tamoutounour S, Potapova S, Foster St. Claire MB, Yuan W, Sen, SK, Dreier MS, Hild B, Hafner M, Wang D, Iliev ID, Belkaid Y, Trinchieri G, Rehermann B#. A natural microbiota-based mouse model with increased translational research value for immune diseases. Science (2019) Aug 2;365(6452)
Muys BR, Sousa JF, Pla.a JR, Ara.jo LF, Sarshad AA, Anastasakis DG, Wang X, Li XL, de Molfetta GA, Ram.o A, Lal A, Vidal DO, Hafner M, Silva WA. miR-450a acts as a tumor suppressor in ovarian cancer by regulating energy metabolism. Cancer Research. (2019) Jul 1;79(13):3294-3305
Gao QQ*, Putzbach WE*, Murmann AE, Chen S, Sarshad AA, Ambrosini G, Bartom ET, Hafner M, and Peter ME. 6mer seed toxicity in tumor suppressive microRNAs. Nature Communications (2018), Oct 29;9(1):4504. doi: 10.1038/s41467-018-06526-1.
Putzbach W*, Haluck-Kangas A*, Gao QQ, Sarshad AA, Bartom E, Stults A, Qadir AS, Hafner M and Peter ME. CD95L mRNA is toxic to cells. Elife (2018) 2018 Oct 16;7. pii: e38621. doi: 10.7554/eLife.38621.
Sarshad AA, Juan AH, Correa Muler AI, Anastasakis D, Wang X, Genzor P, Feng X, Tsai P, Sun H, Haase AD, Sartorelli V, Hafner M. Argonaute-miRNA complexes silence target mRNAs in the nucleus of mammalian stem cells. Molecular Cell. (2018) Sep 20;71(6):1040-1050.e8 doi: 10.1016/j.molcel.2018.07.020.
Tsai P, Dell’Orso S, Rodriguez J, Vivanco KO, Ko K, Jiang K, Juan AH, Sarshad AA, Tran M, Wang D, Wang AH, Anastasakis D, Ralston E, Ried T, Sun H, Hafner M, Larson DR, and Sartorelli V. A Muscle Super-Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription in Trans. Molecular Cell. (2018) Jul 5;71(1):129-141.e8. doi: 10.1016/j.molcel.2018.06.008.
Benhalevy D*, McFarland HL*, Sarshad AA*, Hafner M. PAR-CLIP and streamlined small RNA cDNA library preparation protocol for the identification of RNA binding protein target sites. Methods. (2017) Apr 15;118-119:41-49. doi: 10.1016/j.ymeth.2016.11.009
Putzbach W, Gao QQ, Patel M, van Dongen S, Haluck-Kangas A, Sarshad AA, Bartom ET, Kim KA, Scholtens DM, Hafner M, Zhao JC, Murmann AE, Peter ME. Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism. Elife. (2017) Oct 24;6. pii: e29702. doi: 10.7554/eLife.29702
Dass RA, Sarshad AA, Carson BB, Feenstra JM, Kaur A, Obrdlik A, Parks MM, Prakash V, Love DK, Pietras K, Serra R, Blanchard SC, Percipalle P, Brown AM, Vincent CT. Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. PLoS Genetics. (2016) Aug 8;12(8):e1006217. doi: 10.1371/journal.pgen.1006217.
Dutka T*, Sarshad AA*, Hafner M. PAR-CLIP: A Genomic Technique to Dissect RNA-Protein Interactions. Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing (2016) pp 261-289. Doi 10.1007/978-3-319-31350-4
Al-Muzzaini B, Sarshad AA, Rahmanto AS, Hansson ML, Von Euler A, Sangfelt O. Visa N, Farrants AK, Percipalle P. In β-actin knockouts, epigenetic reprogramming and rDNA transcription inactivation lead to growth and proliferation defects. FASEB Journal (2016) Aug;30(8):2860-73. doi: 10.1096/fj.201600280R.
Al-Muzzaini B, Sarshad AA, Östlund A and Percipalle P. Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation. BMC Biol. (2015) 5;13(1):35. doi: 10.1186/s12915-015-0147-z.
Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Visa N and Percipalle P. Glycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation toactivate rDNA transcription in early G1 cells. PLoS Genetics (2014) 10(6): e1004390. doi:10.1371/journal.pgen.1004390
Sarshad AA and Percipalle P. New insight into role of myosin motors for activation of RNA polymerases. Int Rev Cell Mol Biol. (2014) 311:183-230. doi: 10.1016/B978-0-12-800179-0.00004
Sarshad A*, Sadeghifar F*, Louvet E*, Mori R, Böhm S, Al-Muzzaini B, Vintermist A, Fomproix N, Östlund A and Percipalle P. Nuclear Myosin 1c Facilitates the Chromatin Modifications Required to Activate rRNA Gene Transcription and Cell Cycle Progression. PLoS Genetics (2013) 9(3): e1003397.doi:10.1371/journal.pgen.1003397.